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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well result in an increase in methadone plasma concentrations, which could trigger probably lethal respiratory despair. Furthermore, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also bring about an i